Spray Freeze Drying |
Spray freeze drying is a technique wherein an atomized liquid spray is sprayed into a cryogenic medium, and the spray droplets are quickly frozen. Once frozen, these frozen droplets are lyophilized (freeze-dried) to remove the frozen solvent and leave particles behind. This technique can be used as an alternative to conventional spray drying for thermo-sensitive compounds that have particular issues with the heated chamber and/or gas(ses) used in conventional spray drying, but are retained or reacted as desired with the combination of flash freezing and lyophilization. Such a technique may be of particular interest in the pharmaceutical and food industries, as well as for the production of ceramic powders, and perhaps other fields where conventional spray drying or spray pyrolysis may be typically used. This technique may be used to produce microspheres or other microparticles of various morphologies and compositions. |
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CRYOGENIC ATOMIZER NOZZLE FOR FREEZE DRYING DROPLETS |
Sonaer spray freeze drying atomizer nozzle with extended reach tip easily adapts to cryogenic cells. Nozzle power is controlled by our unique generator which keeps the nozzle in tune with extreme changes in temperature assuring droplets have a narrow distribution for this process. |